Tau Biomarkers in Late-onset Psychosis (LOP)
Jeremy Koppel
Summary
Hallucinations or delusions that occur for the first time in older people with no acute medical problems or mood symptoms may be related to impending dementia. This study aims to confirm this hypothesis using novel blood biomarkers and Positron Emission Tomography (PET) imaging tracers, as well as non-invasive testing.
Description
Psychotic symptoms that occur in advanced age in the absence of an acute medical condition or prominent mood symptoms can represent the late appearance of primary psychotic disorders such as very late-onset schizophrenia-like psychosis (VLOSP) or delusional disorder, or can presage the appearance of a neurodegenerative condition such as Alzheimer's disease (AD). An episode of non-affective psychosis late in life more than doubles the risk of subsequent neurodegenerative disease, with an average time from psychosis to AD diagnosis of 18 months. The biologic mechanisms responsible for the increa…
Eligibility
- Age range
- 65–85 years
- Sex
- All
- Healthy volunteers
- Not specified
Inclusion Criteria: 1. Male or female, aged 65-85 years. 2. Diagnosis of late-onset non-affective primary psychotic disorder consistent with either very late-onset schizophrenia-like psychosis (VLOSP, International Late-Onset Schizophrenia Group consensus criteria, Howard et al., 2000) or delusional disorder (DSM-5 criteria) 3. Caregiver available to provide collateral history and participation in informant-based ratings (NPI,CDR) 4. Clinical Dementia Rating (CDR) score of 0 or 0.5. 5. Mini-Mental State Examination (MMSE) score ≥ 24 and at the screening visit. 6. Normal memory function (to ru…
Interventions
- Diagnostic TestTau PET imaging scan
Subjects will be scanned with novel tau PET tracer \[18F\] PI-2620 to determine whether neurofibrillary tangle pathology is present.
Location
- The Feinstein Institutes for Medical ResearchManhasset, New York