A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Lebrikizumab/ LY3650150 in Adult Participants With Perennial Allergic Rhinitis
Eli Lilly and Company
Summary
The main purpose of this study is to evaluate the efficacy and safety of lebrikizumab in adult participants with perennial allergic rhinitis. Participants can expect study participation to last up to 29.5 months.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Physician-diagnosed perennial allergic rhinitis (PAR). * Has a positive skin prick test (SPT) with indoor allergens and/or positive serum antigen-specific immunoglobulin E (IgE) for indoor allergens ≥0.70 kU/L, utilizing a validated assay (central laboratory). * The participant must have clinical symptoms at study entry associated with positive perennial allergen as tested by the SPT or a positive serum antigen-specific IgE test. * A participant who has a known history of dermatographism or identified during the SPT may participate in this study with a positive serum ant…
Interventions
- DrugLY3650150
Administered SC
- DrugPlacebo
Administered SC
- DrugStandard therapy for INCS
Administered as intranasal spray
Locations (77)
- Allergy and Asthma Specialists Medical GroupHuntington Beach, California
- 310 Clinical ResearchInglewood, California
- Allergy & Asthma Associates of Southern California dba. Southern California ResearchLaguna Niguel, California
- Allergy and AsthmaSan Diego, California
- Asthma and Allergy Associates, PCColorado Springs, Colorado
- Allergy and Asthma Diagnostic CenterTallahassee, Florida