Understanding and Preventing Cortical Mechanisms of Chemotherapy-induced Peripheral Neuropathy
M.D. Anderson Cancer Center
Summary
Cohort 1: To track the onset and progression of a condition called chemotherapy-induced peripheral neuropathy (CIPN). Cohort 2: To track the onset and progression of a condition called chemotherapy-induced peripheral neuropathy (CIPN) and to test a certain type of experimental neuromodulation (stimulation of the brain) with a device called a closed-loop brain-computer interface (clBCI) to see if can help to prevent pain due to CIPN.
Description
Primary Objectives: Objective 1 (Primary Objective): to examine preliminary baseline and serial electrophysiological markers associated with the onset and development of CIPN by tracking brain activity and CIPN symptoms throughout chemotherapy treatment. Secondary Objectives: Objective 2 (Secondary Objective): To preliminarily evaluate whether a clBCI program can regulate changes in EEG that are associated with CIPN while participants are undergoing chemotherapy. Exploratory Objective: Explore whether there are associations between change in brain function and subjective report of CIPN.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion criteria: Objective 1 Inclusion criteria 1. Participants must have the ability to understand and read English, sign a written informed consent, and be willing to follow protocol requirements. 2. ECOG Performance Status of 0-2; 3. Willing to come to MD Anderson for the imaging sessions. 4. Are 18 years of age or above. 5. Have a diagnosis of breast cancer. 6. will receive chemotherapy including doxorubicin, cyclophosphamide, docetaxel, or paclitaxel; Objective 2 Inclusion criteria: 1\) Inclusion criteria: Identical to Objective 1 and are willing to participate in the therapy sessi…
Interventions
- Diagnostic TestElectroencephalogram (EEG)
Measure the electrical activity of your brain before you receive chemotherapy treatment and once monthly for a maximum of 6 measurements.
Location
- MD Anderson Cancer CenterHouston, Texas