Sub-Lingual Administration of Cannabidiol for Knee Osteoarthritis
University of Florida
Summary
Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population. Many physically active Americans have reported pain-relieving effects of cannabidiol (CBD) that can reduce or eliminate use of nonsteroidal anti-inflammatory drugs (NSAIDs) for activity-related pain with minimal to no side effects. Long-term use of over-the-counter medications, including NSAIDs, can pose a significant health risk, and therefore clinical research on the safety and efficacy of CBD is needed.
Description
Knee OA is the most common joint disease and a major cause of functional limitation and pain in adults. Pain is the primary symptom of OA, and the main reason people seek medical treatment. Although pharmacologic treatment for OA such as opioid-based medications may help in the short-term with reducing pain-related symptoms, they are known to have mild to severe side effects along with the potential for long-term dependency. Consequently, many Americans have turned to cannabis-related products like cannabidiol or CBD for reducing pain and pain-related symptoms associated with OA. Current resea…
Eligibility
- Age range
- 40–75 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. established clinical diagnosis of knee osteoarthritis (KOA) 2. moderate to severe knee pain (≥4/10) with physical activity in one or both knees Exclusion Criteria: 1. pregnant (urine pregnancy test) or lactating 2. current cannabis (THC and/or CBD) use (urine drug screen) 3. any prior or ongoing medical condition that, in the investigators' opinion, could adversely affect the safety of the subject 4. any major surgery within 3 months prior to recruitment or planned orthopedic surgery for any time during this study which would interfere with the ability to report pain…
Interventions
- DrugCannabidiol (CBD) Extract
Administered thrice daily (with food) using a sublingual route of administration
- DrugPlacebo
Administered thrice daily (with food) using a sublingual route of administration
Location
- Sports Medicine Research LaboratoryGainesville, Florida