The Prevalence of Neuropathic Pain Pathophysiology Associated With Ankle Fracture
Indiana University
Summary
This application addresses the Peer Reviewed Medical Research Program Investigator-Initiated Research Award FY21 W81XWH-22-CPMRP-IIRA area of Chronic Pain Management Research Program- The investigators will utilize subjects who have sustained ankle fractures and may develop chronic pain following bone union. No attempt will be made to affect the experimental outcome in the subjects. This study will adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of research.
Description
Persistent pain following bone fracture, such as neuropathic pain (NP), is a possible outcome of fracture repair following injury to the ankle and exhibits incidence rates at 1-year post-surgery of 18-42%. This pain state following bone healing (also known as bone union) will be referred to as bone fracture-associated NP (BFNP). Ankle fractures are among the most common surgically-treated fractures in adults, with the greatest incidence occurring in young males. Women are more commonly affected in other age groups. Distal radius fractures are the most common type of fracture for all age groups…
Eligibility
- Age range
- 18–85 years
- Sex
- All
- Healthy volunteers
- Yes
Fracture Group: Inclusion Criteria: 1. 18-85 years old 2. an isolated rotational ankle (AO/OTA 44 types A-C) fracture that is treated operatively 3. Abbreviated Injury Scale \< 3 for non-extremity body systems 4. can speak, read, and understand English Exclusion Criteria: 1. treated for a chronic pain condition prior to their qualifying injury 2. on a pain contract 3. pathologic fracture 4. Daily use of gabapentin or opiods prior to enrollment Control Group: Inclusion Criteria: 1. 18-85 years of age 2. can speak, read, and understand English Exclusion Criteria: 1. Chronic pain or an o…
Location
- Indiana University School of MedicineIndianapolis, Indiana