Yale University
This project tests whether individuals with overweight or obesity and high craving can learn to change their brain response to food cues using neurofeedback, to impact their craving and eating behavior.
Aim 1 of this study is to test whether neurofeedback from the craving network is associated with reduced craving network strength. Aim 2 of this study is to test whether neurofeedback from the craving network is associated with reduced food craving and changes in eating behavior. Aim 3 of this study is to test whether neurofeedback from the craving network is associated with changes in resting state functional connectivity.
Inclusion Criteria: * Ages 18 to 60 years * Body mass index \>25 kg/m2 * \>2.37 Food Craving Inventory score Exclusion Criteria: * Current or past 6 months use of anti-obesity medications * Weight-reduced state defined as \>10% weight reduction in the past 6 months. * Nicotine use * Current diagnosis of neurological or psychiatric disorder * Obesity-related diseases such as type-2 diabetes * Contraindications to MRI * Baseline scanning with motion \>0.15mm frame to frame displacement.
Participants provided with feedback of target brain activation patterns (e.g., thermometer) and will be instructed to try to change the feedback (e.g., decrease the thermometer).
Participants provided with control (sham, yoked to another participant) feedback (e.g., thermometer) and will be instructed to try to change the feedback (e.g., decrease the thermometer).
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