University of Washington
Using the CorTec Brain Interchange (BIC) System, we will examine the effect of a plasticity-inducing therapy regime on the rehabilitation of upper limb impairment post-stroke. This study's main objective is to implement and evaluate neuroplasticity-inducing stimulation. The stimulation methods for inducing neuroplasticity have been selected based on prior preclinical and intraoperative work that has shown promise in providing rehabilitative benefits for stroke patients. We will be structuring this study as an open prospective feasibility study.
Stroke is one of the top three causes of human disability. In middle- and high-income countries around the world, stroke is the leading neurological cause of lost disability-adjusted life years. Motor deficits are among the most common results of stroke and contribute substantially to post-stroke disability. An estimated 6,600,000 American adults have had a symptomatic stroke, with a prevalence that increases with age. Each year, 795,000 people experience a stroke, of which 610,000 are first-ever symptomatic strokes. The mean survival after stroke is 6-7 years, with approximately 85% of patien…
Inclusion Criteria: 22-75 years of age * History of ischemic stroke * Minimum 6 months post-ischemic cortical stroke * Levels of hemiparesis that warrant surgical intervention (upper limb impairment) * Able to participate in a meaningful way in rehabilitation (defined by upper extremity Fugl-Myer (UEFM) score of 25-45 * Disability measured between 3 and 4 on the modified Rankin Scale * Minimum of 30% preservation of the corticospinal pathways in MRI imaging * Observable motor output of the upper limb in response to TMS delivered to the motor cortex * Available for the duration of the study,…
Surgical implantation of the BIC System. This study's main objective is to implement and evaluate neuroplasticity-inducing stimulation. The stimulation methods for inducing neuroplasticity have been selected based on prior preclinical and intraoperative work that has shown promise in providing rehabilitative benefits for stroke patients.
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