Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction: A Randomized Control Trial
The Methodist Hospital Research Institute
Summary
The purpose of this study is to determine if intraosseous (IO) morphine decreases pain and post-operative opioid use in patients undergoing anterior cruciate ligament (ACL) reconstruction.
Eligibility
- Age range
- 18–40 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients of the IRB approved surgeon(s) undergoing ACL reconstruction with bone-to-bone (BTB) autograft * Patients aged between 18-40 years old at the time of surgery Exclusion Criteria: * Patients undergoing ACL reconstruction with any other type of autograft or allograft other than BTB * Patients younger than 18 years old or older than 40 years old * Patients undergoing meniscal root repair or any other repair that changes their weight-bearing status * Patients with a history of substance abuse * Vulnerable populations * Patients on chronic pain medication within the…
Interventions
- DrugIntraosseous Morphine
More recently, intraosseous infusion of analgesics and antibiotics has gained traction in the total joint arthroplasty literature. In knee arthroplasty patients, the combination of a spine and adductor canal block with an intraosseous infusion of morphine into the tibial tubercle prior to incision yielded lower pain in the immediate postoperative period and at 2 weeks, less pain medication use, and significantly better patient-reported outcomes while also reducing systemic opioid exposure in the early postoperative period compared to the spine and adductor block alone.3 No study to date in the available literature has evaluated the efficacy of intraosseous morphine infusion in managing acute postoperative pain in patients undergoing ACL reconstruction with bone-patellar tendon-bone autograft, so that is the intended evaluation point with this project.
Location
- Houston Methodist Research InstituteHouston, Texas