Memorial Sloan Kettering Cancer Center
The purpose of this study is to find out whether N10 chemotherapy is a safe and effective treatment for children with high-risk neuroblastoma.
Inclusion Criteria: * Diagnosis of NB as defined by histopathology, BM metastases plus high urine catecholamine levels, or positivity in MIBG scan. * HR-NB, defined as MYCN-amplified stage L2/M/MS at any age and stage M in patients \>18 months old. * No more than one prior cycle of HR-NB chemotherapy * Age \<19 years. * Signed informed consent indicating awareness of the investigational nature of this treatment. Exclusion Criteria: * Severe dysfunction of major organs, i.e., renal, cardiac, hepatic, neurologic, pulmonary, hematologic, or gastrointestinal toxicity \>/= to grade 3 °Organ d…
DANYELZA is a humanized monoclonal antibody of the IgG1 subclass
Yeast derived recombinant human Sargramostim (GM-CSF)
Cyclophosphamide is an alkylating agent related to nitrogen mustard
Topotecan is a topoisomerase I-inhibitor that is a semisynthetic derivative of camptothecin.
Vincristine is an alkaloid isolated from Vinca rosea Linn (periwinkle).
Doxorubicin is an anthracycline antibiotic
Ifosfamide is a structural analogue of cyclophosphamide
Etoposide for Injection is available as a 20 mg/mL solution in sterile multiple dose vials (5 mL, 25 mL, or 50 mL each).
Carboplatin is available in 50 mg, 150 mg, 450 mg, and 600 mg vials.
Irinotecan hydrochloride trihydrate (CPT-11) is a topoisomerase I inhibitor
Temozolomide is administered intravenously
Between first and second cycle of antibody
Arctuva estimate
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