Effects of a 10-day Western Diet on Cardiometabolic and Immune Function in Midlife Adults
University of Delaware
Summary
This study will implement a Western Diet (WD) to understand cardiometabolic and immune function in middle-aged adults (50- 64 years old). Vascular health, intestinal permeability, and T-cell function will be examined before, during, and after the WD. The WD is a 10-day diet and will consist of 25% of total energy from added sugars.
Description
Aging is the primary risk factor for Alzheimer's disease (AD) which is the most common form of dementia and among the fastest-growing causes of morbidity and mortality in the United States. The risk factors for AD emerge during midlife and are similar to cardiovascular diseases, one of which has particular interest is high blood pressure. The impact of blood vessels and high blood pressure are made worse by poor lifestyle habits, including eating a Western Diet (WD) that contains processed food and high amounts of added sugars (e.g., foods containing high amounts of fructose), with little to n…
Eligibility
- Age range
- 50–64 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * ability to provide informed consent * men and postmenopausal women aged 50-64 years * systolic blood pressure \< 130 mmHg; diastolic blood pressure \< 90 mmHg * body mass index (BMI) \<30 kg/m2 and % body fat \< 25% for men and \< 33% for women * fasting triglycerides \< 200 mg/dl (\< 2.3 mmol/L) * low density lipoprotein (LDL) cholesterol \<160 mg/dl (4.14 mmol/L) * fasting plasma glucose \<126 mg/dl (\<7.0 mmol/L) * weight stable in the prior 6 months (≤ 2 kg weight change) * blood chemistries indicative of normal liver enzymes and renal function (estimated glomerular…
Interventions
- OtherWestern Diet
Consumption of 10 days of a diet high in added sugars (25% of total caloric intake)
Location
- University of DelawareNewark, Delaware