Growth Hormone Resistance of Beta-cells in Women With Gestational Diabetes Mellitus
University of Missouri-Columbia
Summary
The purpose of the research study is to better understand how beta-cells (cells in the pancreas that make insulin and help regulate blood sugar) respond to growth hormone in people with a personal history of gestational diabetes (high blood sugar in pregnancy) at the University of Missouri. The aim of the study is to advance understanding of how growth hormone affects beta-cells and risk factors for developing gestational diabetes and type 2 diabetes.
Eligibility
- Age range
- 18–45 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Singleton, full term pregnancy within the past 5 years * Hemoglobin HbA1c ≤5.6% and fasting blood glucose \<100 mg/dl * Body mass index ≥30.0 kg/m2 and \<45.0 kg/m2, because the majority of women with GDM have overweight/obesity Group specific inclusion criteria: * Gestational Diabetes Group: History of gestational diabetes in the most recent pregnancy * Control Group: no history of gestational diabetes Exclusion Criteria: * Pregnant, planning to become pregnant during the study, or breastfeeding * Current diagnosis or history of type 1 or type 2 diabetes * Use of me…
Location
- University of Missouri School of MedicineColumbia, Missouri