Northwestern University
This phase II trial tests how well zanzalintinib (XL092) works in treating patients with leiomyosarcoma that has spread from where it first started to other places in the body (metastatic) or that cannot be removed by surgery (unresectable). Leiomyosarcomas are a type sarcoma that can occur in any location in the body, such as the uterus or in the abdomen. Current standard treatment for leiomyosarcoma only shows a progression-free survival of 4-6 months. XL092, a tyrosine kinase inhibitor, interferes with cell communication and growth and may prevent tumor growth. Giving XL092 may kill more tumor cells in patients with metastatic or unresectable leiomyosarcoma. The trial has now been expanded to treat additional sarcoma types that are sensitive to tyrosine kinase inhibitors (TKIs) such as translocation-associated soft tissue sarcoma (such as synovial sarcoma), and bone sarcoma (including osteosarcoma and Ewing sarcoma).
PRIMARY OBJECTIVE: I. Evaluate 6-month progression-free survival (PFS) of patients with advanced leiomyosarcoma (LMS), bone sarcoma, or translocation-associated soft tissue sarcoma (TAS) who have been treated with zanzalintinib (XL092) monotherapy. SECONDARY OBJECTIVES: I. Evaluate median progression-free survival (PFS) in patients with advanced leiomyosarcoma (LMS), bone sarcoma, or translocation-associated soft tissue sarcoma (TAS) who have been treated with XL092 monotherapy. II. Determine overall survival (OS) in patients with advanced leiomyosarcoma (LMS), bone sarcoma, or translocati…
Inclusion Criteria For Cohort 1 - Leiomyosarcoma: * Patients must have histologically confirmed leiomyosarcoma that has been clinically determined to be metastatic or unresectable. Pathology must have been reviewed at a National Comprehensive Cancer Network (NCCN) designated cancer center such as Northwestern University's Lurie Cancer Center. * Patients must have undergone at least 2 or more lines of antineoplastic treatment, but no more than 2 lines of treatment can be a tyrosine kinase inhibitor (TKI). Inclusion Criteria For Cohort 2 - Bone Sarcoma: * Patients must have histologically con…
Undergo blood sample collection
Undergo CT
Undergo ECHO
Undergo MUGA
Given PO