Stanford University
This study aims to evaluate the efficacy of deep transcranial magnetic stimulation (dTMS) as a treatment for Veterans with a methamphetamine use disorder (MUD).
To date, TMS has emerged as a promising treatment avenue for addiction and is being tested in clinical trials with some encouraging results. A recent systematic review and meta-analysis highlights that 7/8 (87.5%) studies using TMS for MUD or 38/50 (88%) in addiction more broadly have targeted the left DLPFC alone. While this strategy has been useful in reducing craving, treated individuals resume use shortly after treatment at similar rates to those receiving sham. Here, utilizing a data-driven and innovative approach, the investigators aim to modulate target brain function that has been show…
Inclusion: * Must be within the age range of 25-75. * Participants must meet Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for moderate to severe MUD (≥4 diagnostic symptoms). * Participants must be able to obtain a Motor Threshold (MT), which will be determined during the screening process. * Participants must have an adequately stable condition and environment to enable attendance at scheduled clinic visits. * Participants must be able to read, verbalize, understand, and voluntarily sign the Informed Consent Form prior to participation in study procedur…
The study will utilize the H4 coil to administer active Deep Transcranial Magnetic Stimulation (dTMS) to the bilateral insula, a core salience network node.
The study will utilize an identical protocol using the H4 coil to administer a sham condition.
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