A Phase Ia/Ib, Open-label, Dose-escalation, and Dose-expansion Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamic of UBX-303061 in Subjects With Relapsed/Refractory B-Cell Malignancies
Ubix Therapeutics, Inc.
Summary
This is a first-in-human Phase 1a/1b multicenter, open-label study designed to evaluate the safety and anti-cancer activity of UBX-303061 in patients with relapsed/refractory B-cell malignancies.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Key Inclusion Criteria * Capable of giving signed informed consent * Age ≥18 years * ECOG performance status ≤2. * Phase Ia (dose-escalation part only): Subjects with relapsed and/or refractory B-cell malignancies (CLL/SLL, DLBCL, FL, MCL, WM or MZL) who have received at least 2 prior therapies and for subjects with no available treatment options as per the Investigator's discretion. * Phase Ib (dose-expansion only): Subjects with relapsed and/or refractory B-cell malignancies who have received at least 2 prior therapies and for subjects with no available treatment options as per the Investig…
Interventions
- DrugUBX-303061
UBX-303061 oral dosage
Locations (11)
- University of MichiganAnn Arbor, Michigan
- Gabrail Cancer CenterCanton, Oklahoma
- MD Anderson Cancer CenterHouston, Texas
- MICS Centrum Medyczne ToruńTorun, Kuyavian-Pomeranian Voivodeship
- Pratia, MTZ Clinical ResearchWarsaw, Mazowieckie Voivodeship
- Pratia, Oncology KatowiceKatowice, Silesian Voivodeship