A Phase 1/2a, Open-label, Dose-finding Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of BMS-986507 (BL-B01D1) Combinations in Adult Participants With Advanced Solid Tumors
Bristol-Myers Squibb
Summary
The purpose of this study is to evaluate the safety, tolerability, drug levels, and preliminary efficacy of BMS-986507 combinations in adult participants with advanced solid tumors.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria * Participants must have at least one measurable lesion per response evaluation criteria in solid tumors. * Participants must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1. * Participants must have a life expectancy of at least 3 months at the time of the first dose. * Group A: Participants must have pathologically confirmed locally advanced or metastatic NSCLC with an EGFR exon 19 deletion or L858R mutation in exon 21, either alone or in combination with other EGFR mutations, which may include T790M in exon 20. Participants with other EGFR…
Interventions
- DrugBMS-986507
Specified dose on specified days
- DrugOsimertinib
Specified dose on specified days
- DrugPembrolizumab
Specified dose on specified days
- DrugNivolumab
Specified dose on specified days
- DrugPumitamig
Specified dose on specified days
Locations (64)
- University of Alabama at BirminghamBirmingham, Alabama
- University of Miami Hospital and Clinics, Sylvester Cancer CenterMiami, Florida
- Local Institution - 0125Maywood, Illinois
- Local Institution - 0065Iowa City, Iowa
- John Theurer Cancer Center at Hackensack University Medical CenterHackensack, New Jersey
- Cleveland ClinicCleveland, Ohio