VA Office of Research and Development
The purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. The investigators are also interested in how changes in hormones that might be different in men and women could affect how lifestyle interventions change these brain responses.
The purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. The investigators are also interested in how changes in hormones that might be different in men and women could affect how lifestyle interventions change these brain responses. This will help us to better understand how different lifestyle interventions affect the brain and how this might relate to various behaviors. Eligible participants will be asked to complete 2 study day…
Inclusion Criteria: * Veteran * Body mass index (BMI) of 25 or greater * Physically inactive * Able to attend study visits in person in Aurora, CO Exclusion Criteria: * Currently pregnant * History of bariatric surgery * Current eating disorder * Current treatment with appetite-altering medications (e.g., glucagon-like peptide-1 (GLP-1) agonists) * Contraindication to MRI (weight \> 500 pounds (lbs); claustrophobia; metal or electronic devices in the body) * Cardiovascular disease, chronic kidney disease, pulmonary disease, or diabetes * Unable to exercise due to cardiac, pulmonary, neurolo…
12 weeks of aerobic exercise, with 4 sessions per week.
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