A Phase 1, First-in-Human Study of MEN2312, a KAT6 Inhibitor, as Monotherapy and in Combination in Participants With Advanced Breast Cancer
Stemline Therapeutics, Inc.
Summary
This is a first-in-human study of MEN2312, a lysine acetyltransferase 6 (KAT6) inhibitor, in adult participants with advanced breast cancer.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Key Inclusion Criteria: * Participant has advanced (locoregionally recurrent or metastatic) breast cancer not amenable to curative therapy. * Participant must have received at least one prior line of endocrine therapy for advanced/metastatic disease or participant who has radiological evidence of breast cancer recurrence or progression during or within 12 months from the end of or during adjuvant treatment with endocrine therapy, as these participants are considered as first-line relapsed participants. Progression on previous cyclin-dependent kinase 4/6 inhibitor treatment in combination with…
Interventions
- DrugMEN2312
MEN2312 administered as oral tablets.
- DrugElacestrant
Elacestrant administered as oral tablets.
Locations (32)
- Highlands Oncology GroupSpringdale, Arkansas
- UC San Diego Moores Cancer CenterLa Jolla, California
- Stanfod Cancer CenterPalo Alto, California
- UCSF Helen Diller Family Comprehensive Cancer CenterSan Francisco, California
- UCLA Hematology Oncology - ParksideSanta Monica, California
- Yale Comprehensive Cancer CenterNew Haven, Connecticut