Intraosseous Vancomycin and Cefazolin vs Intravenous Administration in Primary Total Knee Arthroplasty

Summary

The goal of this clinical trial is to compare the efficacy of intravenous (IV) and intraosseous (IO) antibiotic administration techniques during primary total knee arthroplasty (TKA) in adults undergoing a TKA procedure at Houston Methodist Hospital. The main questions it aims to answer are: Does IO administration of vancomycin and cefazolin protect against perioperative exposure risks? Is there a difference in post-operative complication rates between IV and IO administration of these drugs? Participants will be randomized to receive either the standard of care IV administration of Vancomycin and Cefazolin, or the IO administration of Vancomycin and Cefazolin.

Eligibility

Age range

18+ years

Sex

All

Healthy volunteers

No

Interventions

• Drug
  IO Administration of Cefazolin

  Intraosseous injection of cefazolin to guard against infection.

• Drug
  IO Administration of Vancomycin

  Intraosseous injection of vancomycin to guard against infection.

• Drug
  IV Administration of Cefazolin

  Intravenous dose of cefazolin to guard against infection.

• Drug
  IV Administration of Vancomycin

  Intravenous dose of vancomycin to guard against infection.

Location