Pharmacokinetics of Oral Calcium Carbonate in Parturients
Stanford University
Summary
This study investigates the time course of change in calcium in the blood after a pregnant subject takes an oral dose of calcium carbonate (commonly marketed as "Tums"). This information is important for trials investigating whether calcium can reduce postpartum hemorrhage, bleeding after delivery.
Eligibility
- Age range
- 18–45 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Pregnant female subjects at the study institution, admitted for labor (spontaneous, augmented, or induced) Exclusion Criteria: 1. severe range blood pressure (BP \>160/\>110) within the 48 hours prior to delivery 2. patient age \<18 years or \>45 years 3. renal dysfunction with a documented serum Cr \> 1.0 mg/dL 4. known history of congenital or acquired cardiac disease or history of arrhythmia 5. patient taking digoxin 6. patient currently taking a calcium channel blocker 7. Weight \<55kg or \>100kg, or 8. receiving magnesium infusion within 24 hours prior to or durin…
Interventions
- DrugOral calcium carbonate
All participants receive a single, open-label dose of oral calcium carbonate 3000mg
Location
- Stanford Children's Health, Lucile Packard Children's HospitalStanford, California