Multicenter Open-Label Feasibility Study of Intraoperative Nerve and Ureter Visualization With Bevonescein in Patients Undergoing Minimally Invasive Abdominopelvic Surgery
Alume Biosciences, Inc.
Summary
Feasibility study of Bevonescein to highlight Nerves and Ureter in patients undergoing Minimally Invasive Surgery
Description
This study will evaluate the safety, tolerability and efficacy of Bevonescein administered as an intravenous (IV) infusion to patients undergoing minimally invasive surgery. This study will also characterize the pharmacokinetic of Bevonescein in this subject population and determine the dose of Bevonescein needed to generate a fluorescence signal in nerve and ureter tissue to enable fluorescence recordings and image analysis with an imaging system.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Must be a minimum of 18 years of age * Study participant is planning to proceed with surgery * Willing to provide informed consent * Sexually active patients must be willing to use an acceptable form of contraceptive while participating and 30 days after. * Females of childbearing potential must have a negative pregnancy test at screening and during the study. Exclusion Criteria: * Patient has had prior surgery at the intended surgical site. * Patient has abnormal cardiac rhythm not controlled by medication. * Patient has moderate to severe renal impairment. * Patient…
Interventions
- DrugBevonescein
Bevonescein is a sterile solution that is intravenously administered
Location
- University of California San DiegoSan Diego, California