Prophylactic Amnioinfusion for Prevention of Postpartum Hemorrhage: A Randomized Clinical Trial (PURPOSE)
The University of Texas Health Science Center, Houston
Summary
The purpose of this study is to decrease the likelihood of composite postpartum hemorrhage (PPH) morbidity, which consists of i) Estimated or quantified blood loss of 1,500 mL or more, ii) transfusion of any blood products or iii) hysterectomy
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Singletons with a gestational age of 34.0 weeks or more * Labor (spontaneous or medical induction) * Medium- or High-risk for PPH, as described by American College of Obstetricians and Gynecologists (ACOG) Exclusion Criteria: * Scheduled cesarean delivery * Multiple gestations * Delivery at \< 34.0 weeks * Contraindication to place intrauterine pressure catheter (e.g. HIV) * Incarcerated subjects * Major fetal anomalies requiring neonatal surgical intervention * Stillbirth on admission
Interventions
- Combination ProductSaline delivered using an intrauterine pressure catheter (IUPC)
An intrauterine pressure catheter (IUPC) will be placed in participants after membrane rupture, or at 4 cm if membranes previously ruptured. A 300cc bolus of normal saline will be administered. A continuous rate of 100 cc/hr of normal saline will continue until delivery to prevent Postpartum Hemorrhage. If the IUPC is dislodged, it will be replaced by a trained clinician.
Location
- The University of Texas Health Science Center at HoustonHouston, Texas