Effects of a Hemp Product on the Pharmacokinetics and Pharmacodynamics of Clopidogrel
Washington State University
Summary
The goal of this clinical trial is to determine how two different doses of cannabidiol (CBD), given as a hemp product, change the blood concentrations of the drug clopidogrel in the body. Results will be used to help design future studies and to assist healthcare providers in informing their patients about the safe use of CBD.
Description
The popularity of cannabis products has grown exponentially over the past decade as several states continue to decriminalize or legalize recreational and/or medicinal use. Cannabis contains \>500 phytoconstituents, including \>100 cannabinoids. The most well-studied cannabinoids are tetrahydrocannabinol (THC) and cannabidiol (CBD). Although both are psychoactive, THC produces the characteristic "high," while CBD does not. CBD is available as a prescription drug (Epidiolex®) to treat seizure disorders. Hemp, a popular CBD-containing botanical product, is defined as containing \<0.3% THC. Hemp w…
Eligibility
- Age range
- 21–64 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * 21-64 years old and healthy; * Confirmed by genetic test to be a CYP2C19 normal, rapid, or ultra-rapid metabolizer; * Not taking any medications (prescription and non-prescription, including clopidogrel) or dietary supplements/botanical products known to alter the pharmacokinetics of cannabis and/or clopidogrel; * Have taken hemp or cannabis (in any form) before and tolerated it well; * Willing to abstain from consuming dietary supplements/botanical products and citrus juices for the duration of the study; * Willing to abstain from cannabis/marijuana, hemp, THC- and/or C…
Interventions
- DrugCannabidiol in the form of hemp
Cannabidiol (30 mg) in the form of an orally administered hemp oil softgel
- DrugClopidogrel
75 mg oral clopidogrel
Location
- Washington State University College of Pharmacy and Pharmaceutical SciencesSpokane, Washington