A Phase 2, Open-label, Multicenter Study to Evaluate Efficacy and Safety of Zanidatamab for the Treatment of Participants With Previously Treated HER2-expressing Solid Tumors (DiscovHER PAN-206)
Jazz Pharmaceuticals
Summary
The purpose of this study is to evaluate the efficacy and safety of zanidatamab for the treatment of participants with previously treated solid tumors that have Human Epidermal Growth Factor Receptor 2 (HER2) Immunohistochemistry (IHC) 3+ overexpression.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Is at least 18 years of age inclusive at the time of signing the informed consent 2. Participants with locally advanced, unresectable, or metastatic solid tumors (except Biliary Tract Cancer (BTC), defined as gallbladder cancer or cholangiocarcinoma) who have progressed following at least 1 prior systemic treatment for metastatic or advanced disease and have no available treatment options that have confirmed benefit. Prior treatment with HER2-targeted therapy is not permitted (Cohort 1 only). For participants with breast cancer (Cohort 2) or GEA (Cohort 3), prior HER2-t…
Interventions
- DrugZanidatamab
Administered by intravenous (IV) infusion
Locations (21)
- Arizona Oncology Associates, PC - NAHOAPrescott, Arizona
- Rocky Mountain Cancer CenterLittleton, Colorado
- Florida Cancer Specialists - SouthFort Myers, Florida
- Florida Cancer Specialists - Lake NonaOrlando, Florida
- Florida Cancer Specialists - NorthSt. Petersburg, Florida
- Florida Cancer Specialists - EastWest Palm Beach, Florida