A Phase 1/2 Study of BMS-986482 as Monotherapy or Combination Therapy in Participants With Advanced Solid Tumors
Bristol-Myers Squibb
Summary
The purpose of this study is to test the safety and efficacy of BMS-986482 alone and as combination therapy in participants with advanced solid tumors.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * All participants must have a histologically or cytologically confirmed, advanced, unresectable/metastatic, solid malignancy measurable by RECIST v1.1, and have received, be refractory to, ineligible for, intolerant of, or refused existing therapy(ies) known to provide clinical benefit for the condition of the participant. * Participant must be ≥ 18 years or the legal age of consent in the jurisdiction in which the study is taking place, inclusive, at the time of signing the ICF. Exclusion Criteria: * History of life threatening immune mediated toxicity related to prior…
Interventions
- DrugBMS-986482
Specified dose on specified days
- DrugNivolumab and rHuPH20
Specified dose on specified days
- DrugNivolumab/relatlimab/rHuPH20
Specified dose on specified days
- DrugBevacizumab
Specified dose on specified days
Locations (21)
- University of California, Irvine (UCI) Health - UC Irvine Medical CenterIrvine, California
- The Angeles Clinic and Research Institute - West Los Angeles OfficeLos Angeles, California
- Local Institution - 0008Aurora, Colorado
- John Theurer Cancer Center at Hackensack University Medical CenterHackensack, New Jersey
- Northwell Health/ RJ Zuckerberg Cancer CenterLake Success, New York
- Levine Cancer InstituteCharlotte, North Carolina