A Phase 1, Open-Label Study in Healthy Volunteers to Evaluate the Relative Bioavailability of NX-5948 Tablets Compared to Capsules, and the Effect of Food and an Acid-reducing Agent on the Pharmacokinetics of NX-5948
Nurix Therapeutics, Inc.
Summary
This is a multiple part, multiple cohort study evaluating the relative bioavailability, food effect, and drug-drug interaction of NX-5948 in healthy volunteers.
Eligibility
- Age range
- 19–55 years
- Sex
- All
- Healthy volunteers
- Yes
Key Inclusion Criteria: * Healthy, adult, male or female 19-55 years of age * Continuous non-smoker who has not used nicotine and tobacco-containing products for at least 3 months prior to the first dosing * Body mass index (BMI) ≥ 18.0 and ≤ 32.0 kg/m2 * Medically healthy with no clinically significant medical history, physical examination, clinical laboratory profiles, vital signs, or 12-lead safety ECGs at the screening visit, as deemed by the PI or designee * Understands the study procedures in the informed consent form (ICF) and be willing and able to comply with the protocol. Key Exclu…
Interventions
- DrugNX-5948
Administered orally in tablet or capsule form
- DrugEsomeprazole
Administered orally in capsule form
Location
- CelerionLincoln, Nebraska