A Pilot Assessment of the Safety and Efficacy of Pleural Irrigation for Retained Pleural Infection Using a Novel Irrigation Device
Beth Israel Deaconess Medical Center
Summary
Single-arm pilot trial of the use of intrapleural saline irrigation to treat retained pleural infections for patients with contraindications to standard of care intrapleural enzymatic therapy.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Retained pleural effusion identified via bedside ultrasound within the first 24 hours after chest tube insertion * Patient is contraindicated from receiving intrapleural enzymatic therapy within the first 24 hours after chest tube insertion Exclusion Criteria: * Non-infectious cause of pleural fluid analysis findings listed above identified (e.g. malignancy) * Post-procedural empyema or complicated parapneumonic effusion
Interventions
- Deviceof intrapleural saline irrigation with CLR irrigator
patients will have a CLRTM port and CLRTM irrigator (CLR Medical, Calverton, MD, USA) added to their chest tube and atrium circuit to facilitate pleural irrigation.
Location
- Beth Israel Deaconess Medical CenterBoston, Massachusetts