A Phase 1/2a, Multicenter, Open-label, First in Human Study of BMS-986490 With or Without Bevacizumab in Advanced Solid Tumors
Bristol-Myers Squibb
Summary
This is a study of BMS-986490 as a monotherapy and in combination with bevacizumab in participants with select advanced solid tumors known to express CEACAM5.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Documented histologically or cytologically confirmed, advanced, unresectable/metastatic solid tumor measurable by RECIST v1.1. * CRC: Part 1A, Part 2A-CRC, Part 1B, and Part 2B: i) Locally advanced/metastatic, recurrent, or unresectable CRC with adenocarcinoma histology and whose disease has progressed after systemic cancer therapy in the metastatic or adjuvant setting including 5-FU, irinotecan, and/or oxaliplatin (if available and not contraindicated). * NSCLC: Part 2A-NSCLC/GC, 2L+ NSCLC: i) Histologically confirmed NSCLC meeting stage criteria for Stage IIIB, S…
Interventions
- DrugBMS-986490
Specified dose on specified days.
- DrugBevacizumab
Specified dose on specified days.
Locations (6)
- USC/Norris Comprehensive Cancer CenterLos Angeles, California
- START MidwestGrand Rapids, Michigan
- John Theurer Cancer Center at Hackensack University Medical CenterHackensack, New Jersey
- UPMC Hillman Cancer CenterPittsburgh, Pennsylvania
- Tasman Oncology ResearchSouthport, Queensland
- Princess Margaret Cancer CentreToronto, Ontario