Femoral Bone Mineral Density (BMD) Change Following Cemented or Cementless Total Knee Arthroplasty
University of Wisconsin, Madison
Summary
The purpose of this study is to examine femur bone mineral density (BMD) change before and after surgery in patients receiving cemented or cementless total knee arthroplasty (TKA). performed with manual or robotic methods. 100 participants will be enrolled and can expect to be on study for up to 26 months.
Description
It has previously been reported that total knee arthroplasty (TKA) causes major femur bone loss (\~18% within 1 year). Prior studies did not examine different surgical methods, such as the use of cement or robotics, in TKA. The investigators hypothesize that previously reported differences in distal femur BMD change following TKA exist between patients receiving cemented vs. cementless prostheses. Specific Aim 1: In the entire study cohort, our primary endpoint is to estimate percent BMD change 12 and 24 months after TKA at the distal femur 25% region of interest (ROI). Specific Aim 1a: To c…
Eligibility
- Age range
- 55+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients age greater than or equal to 55 years undergoing TKA with no prior total joint arthroplasty on the surgical side * Normal BMD or osteopenia with Fracture Risk Assessment Tool (FRAX) not meeting Bone Health and Osteoporosis Foundation (BHOF) treatment recommendations, i.e., 10-year major osteoporotic fracture risk greater then or equal to 20 percent or hip fracture risk greater than or equal to 3 percent. Exclusion Criteria: * Known clinical osteoporosis defined as any one of the following: * Hip or spine T-score less than or equal to -2.5 * History of low…
Interventions
- ProcedureCement
The cemented approach includes inserting cement into the femur and tibia prior to setting the prosthetic.
- OtherCementless
The non-cement approach uses a different type of prosthetic that is placed tight against the bone and requires no other fixation material.
- ProcedureManual Surgery
The manual approach is the surgeon determining prosthetic placement using techniques developed during training.
- ProcedureRobotic Surgery
The haptic robotic assisted approach uses a computer and robot to determine specific placement of the prosthetic.
Location
- UW School of Medicine and Public HealthMadison, Wisconsin