Non Alcoholic Fatty Liver Disease and Endogenous Oxalate Synthesis
University of Alabama at Birmingham
Summary
This study aims to determine the daily rate of endogenous synthesis of oxalate using fasted urine collection and a low-oxalate controlled diet in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Description
Urinary oxalate excretion is derived from both dietary sources and endogenous synthesis. This study will use a low-oxalate controlled diet, repeat fasted urine collections and 24-hr urine collections on a low-oxalate diet, to determine the daily rate of endogenous oxalate synthesis in individuals with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * age \>18 years * History of MASLD, with liver fat content \> 5% * Normal kidney function * Stable medication for at least 1 month for diabetes mellitus if any * Willingess to ingest fixed diets and stop dietary supplements for the study and come to UAB for visits Exclusion Criteria: * Age \< 18 years * Inaccurate 24-hour urine collections * Liver fat content \<5% * Liver cirrhosis * Evidence of other chronic liver disease, viral hepatitis * history of alcoholism within 2 years of enrollment * Contra-indication to Magnetic Resonance Imaging * Chronic kidney disease with…
Interventions
- Dietary SupplementLow-oxalate fixed diet
Ingestion of a low-oxalate (\< 60 mg/day) , normal calcium (800-1200 mg/d) eucaloric diet for 5 days
Location
- University of Alabama at BirminghamBirmingham, Alabama