Pathogenic Mechanisms of Obesity and Its Cardiometabolic Complications
Yale University
Summary
Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in youth with obesity.
Description
Pediatric obesity is a major health burden affecting millions of children and adolescents as it predisposes to the development of cardio-metabolic diseases early in life, such as insulin resistance, fatty liver disease and type 2 diabetes. Investigators have recently completed a series of studies to understand the relationship between the intestinal microbial activity and human metabolism in youth. It was observed that intestinal fermentation, a process through which fermentable carbohydrates are processed by intestinal bacteria, results in a variety of biological responses aimed at protecting…
Eligibility
- Age range
- 15–22 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age 15 to 22 years * In puberty (girls and boys: Tanner stage III-V); * BMI \>85th Exclusion Criteria: * Pregnancy; * endocrinopathies (e.g., Cushing syndrome); * substance abuse; * medications affecting insulin resistance such as metformin, GLP-1 analogues; - * high fibers intake (\> 30g/day) as assessed by a 3-day food record.
Interventions
- OtherLactulose Oral Product
Each arm will undergo a study to induce colonic fermentation through lactulose at the beginning and at the end of the 12 weeks.
Location
- Yale UniversityNew Haven, Connecticut