Comparison of Varying Doses of Steroid for Intra-articular Knee Injections
Mayo Clinic
Summary
The purpose of this study is to assess obese patients with knee arthritis and determine the non-inferiority of a low dose steroid treatment vs. standard dose steroid treatment for two knee outcome measures: pain and function.
Eligibility
- Age range
- 55–85 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: • Patients with BMI ≥30 kg/m2 and radiograph-proven knee osteoarthritis who are interested in receiving a steroid injection for knee arthritis. Exclusion Criteria: * BMI \< 30 kg/m2 * Uncontrolled diabetics with a hemoglobin A1c \> 8% * No other treatment within the time frame of the study. * Patients that are undergoing physical therapy at the time of the study.
Interventions
- DrugTriamcinolone Acetonide Low Dose
Subjects will receive a reduced dose of 20mg of triamcinolone acetonide. Total injection volume of 5ml, consisting of: * 0.5ml triamcinolone acetonide (20mg) * 4.5ml lidocaine (45mg)
- DrugTriamcinolone Acetonide Standard Dose
Subjects will receive the standard of care dose of 40mg triamcinolone acetonide Total injection volume of 5ml, consisting of: * 1ml triamcinolone acetonide (40mg) * 4ml lidocaine (40mg)
Location
- Mayo Clinic in FloridaJacksonville, Florida