Influence of Lidocaine Infusion on Motor Evoked Potential Thresholds; a Single-center, Double-blinded, Randomized Trial for Patients Undergoing Spin Surgery With Intraoperative Neurophysiologic Monitoring.
Dartmouth-Hitchcock Medical Center
Summary
The purpose of this study is to determine the effect of lidocaine infusion on intraoperative neuromonitoring in patients undergoing spine surgery.
Description
The investigators will compare the stimulation threshold for motor evoked potentials (MEPs) for patients undergoing spine surgery with intraoperative neurophysiologic monitoring (IONM) who receive a lidocaine infusion vs. normal saline (NS) infusion. The endpoint for this objective will be the final stimulation threshold for MEPs at the end of the surgery. The stimulation threshold for MEPs is a commonly used metric to determine the effects of anesthetic agents on MEP signals. Secondary objectives will somatosensory evoked potentials (SSEPs) with an endpoint of amplitude and latency of SSEPs t…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Patients undergoing elective cervical or thoracolumbar spine surgery with intraoperative neurophysiological monitoring Exclusion Criteria: * Inability to provide informed consent in English * Pregnancy (based on patient report or a positive test on the day of surgery) * Contraindication to lidocaine * Planned post-operative intubation * Current incarceration
Interventions
- DrugLidocaine in Saline
Lidocaine infusion 1.5 mg/kg/hr
- DrugNormal saline
Normal saline infusion
Location
- Dartmouth Hitchcock Medical CenterLebanon, New Hampshire