A Phase 1, Open-Label Dose Escalation and Expansion Study of PT0253 in Participants With KRAS G12D Mutated Advanced Solid Tumors

Inclusion Criteria: 1. Histologically or cytologically confirmed advanced or metastatic solid malignancy 2. Participant has a pathologically documented, locally advanced or metastatic malignancy with KRAS p.G12D mutation identified through molecular testing using a Clinical Laboratory Improvement Amendments (CLIA) certified, validated institutional or commercial test. 3. Measurable disease (RECIST 1.1 Criteria). 4. Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1. 5. Willingness to avoid pregnancy or fathering children from screening through 90 days after the last dose of s…