Dysregulation of Whole-body Metabolism in Ovarian Cancer: A Longitudinal Study
University of Tennessee Graduate School of Medicine
Summary
Minimal information is available regarding changes in whole-body metabolism in ovarian cancer patients, and no study has assessed whole-body lipid metabolism in this patient population. In this pilot study we will assess fasting and postprandial lipid metabolism of ovarian cancer patients before, during, and after treatment via indirect calorimetry.
Description
Ovarian cancer is one of the deadliest gynecological diseases, with a 5-year survival rate of only 49%. It is well established that cancer cells have fundamentally altered metabolism, which contributes to proliferation and metastasis. Recent findings in the field have recognized that lipid metabolism is altered in ovarian cancer cells, with cells utilizing lipids as a primary energy source. Due to the high demand of energy from tumor cells, it's possible that other non-malignant tissues could reprogram their metabolism to create an environment that supports tumor growth. Minimal information is…
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Women * Age \>18 * Presumed ovarian cancer diagnosis (i.e. those being clinically evaluated for suspicion of ovary cancer) * Planned treatment course for ovarian cancer involving cytoreductive surgery followed by chemotherapy * Availability to commit to attending all study visits * Internet access and consistent access to phone/email/text communication Exclusion Criteria: * Pregnancy * Inability to provide voluntary informed consent * Inability to consume the pre-study visit meal/snack and/or the study visit meal due to strict dietary restrictions * Illicit substance u…
Interventions
- OtherHigh fat smoothie
Participants will consume a standardized 490 kcal high-fat smoothie, consisting of 57% fat, 23% carbohydrate, and 20% protein.
Location
- University of Tennessee Graduate School of MedicineKnoxville, Tennessee