Novel Strategies for Reducing Burn Scar Itch
The University of Texas Medical Branch, Galveston
Summary
The purpose of the study is to see whether using diphenhydramine (Benadryl), famotidine (Pepcid), and cromolyn sodium will decrease burn scar itch.
Description
The purpose of this study is to examine the effect of a new approach to treating burn scar itch. In other patient populations experiencing itch, H2 antihistamines and/or topically applied cromolyn sodium have decreased itch. We believe that these medications will reduce itch from burn scars. To test this idea, the investigators will compare two methods of treating itch: 1) recommended oral diphenhydramine (Benadryl) with placebo capsule and placebo lotion and 2) recommended oral diphenhydramine (Benadryl) with administration of oral famotidine (Pepcid) and topically applied cromolyn sodium.
Eligibility
- Age range
- 18–80 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Participants must meet all the inclusion criteria in order to be eligible to participate in the study. * Participant has provided informed consent in a manner approved by the IRB and is willing and able to comply with the trial procedures. * Adults: ≥18 to \<80 years of age. * Has an itchy burn scar. Exclusion Criteria: Participants meeting any of the exclusion criteria at baseline will be excluded from study participation. * Failure to obtain consent or unable to return for follow up assessments. * Patient is unable to follow the protocol required assessments. * Membe…
Interventions
- Combination ProductFamotidine and 4% topical cromolyn sodium
Patients will be instructed to take a 20mg famotidine capsule twice daily, and to use the lotion (4% cromolyn sodium) twice daily.
- OtherPlacebo
Treatment with active H1 antihistamine plus administration of placebo famotidine and placebo cromolyn sodium.
Location
- University of Texas Medical Branch, GalvestonGalveston, Texas