Parent-to-Child Nasal Microbiota Transplant to Reestablish Nasal Microbiome Diversity After Intranasal Mupirocin Treatment of Children With Staphylococcus Aureus Nasal Colonization
Johns Hopkins University
Summary
This protocol aims to evaluate how NMT affects pediatric nasal microbiome diversity following intranasal mupirocin treatment
Description
This parent-to-child NMT study will test the effect of an anterior nares, or nasal, microbiota transplant (NMT) on seeding, engraftment, and diversity of the neonatal microbiome following nasal decolonization for S. aureus. Infants admitted to the Johns Hopkins Neonatal Intensive Care Unit (NICU) will be screened and parents will be approached for enrollment in the study. After consent and baseline screening of parents and infants, eligible infants will undergo an NMT.
Eligibility
- Age range
- 0–60 years
- Sex
- All
- Healthy volunteers
- Yes
Child: Inclusion criteria 1. Child has had a prior nasal surveillance culture grow S. aurues 2. Child is \<18 years of age 3. Child completed treatment with intranasal mupirocin for S. aureus nasal colonization as part of routine clinical care two or more days before the planned transplant 4. Child has anticipated hospital length of stay \>3 days after completing intranasal mupirocin treatment 5. Infant \>25 weeks gestation unless \>2 months chronological age Exclusion criteria 1. Child is a ward of the State 2. Child with a diagnosis of immunodeficiency or antenatal suspicion for immunode…
Interventions
- BiologicalNasal Microbiota Transplant (NMT)
nasal microbiota transplant
- BiologicalPlacebo
Placebo sterile swab
Location
- Johns Hopkins UniversityBaltimore, Maryland