A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of JNJ-77242113 for the Treatment of Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis
Janssen Research & Development, LLC
Summary
The purpose of this study is to evaluate the efficacy of icotrokinra (JNJ-77242113) compared to placebo in biologic-experienced and biologic-naive participants with active psoriatic arthritis (PsA) by assessing the reduction in signs and symptoms of PsA.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Have active psoriatic arthritis (PsA) despite current or previous use of greater than or equal to (\>=) 1 of the following: a. Non-biologic disease-modifying antirheumatic drug (DMARD) therapy; b. Apremilast therapy; c. Biologic-agent (limited to only 1) * Have a diagnosis of PsA for at least 3 months before the first administration of study intervention and meet classification criteria for Psoriatic Arthritis (CASPAR) at screening * Have active PsA as defined by: (a) At least 3 swollen joints and at least 3 tender joints at screening and at baseline (b) C-reactive prote…
Interventions
- DrugIcotrokinra
Icotrokinra will be administered.
- DrugPlacebo
Placebo will be administered.
Locations (214)
- AARA Clinical ResearchGlendale, Arizona
- AARA Clinical Research 1Mesa, Arizona
- Arthritis and Rheumatism Associates ARA JonesboroJonesboro, Arkansas
- Clinical Research of West FloridaClearwater, Florida
- Omega Research ConsultantsDeBary, Florida
- Suncoast Clinical ResearchNew Port Richey, Florida