A Phase 2 Study of Outpatient Epcoritamab as Second Line Therapy in Non-Transplant Eligible Relapsed/Refractory Large B-cell Lymphoma
Massachusetts General Hospital
Summary
The purpose of this study is to measure the efficacy of the study drug, epcoritamab, in participants with relapsed/refractory large B-cell lymphoma.
Description
This is a phase 2 study of outpatient administration of epcoritamab in non-transplant eligible large B-cell lymphoma that has relapsed after, or is refractory to, 1 prior line of therapy. Phase II clinical trials test the safety and effectiveness of an investigational drug to learn whether the drug works in treating a specific disease. "Investigational" means that the drug is being studied. The U.S. Food and Drug Administration (FDA) has approved epcoritamab as a treatment option for your disease after at least two prior treatments. The study treatment may continue for up to 24 cycles or un…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Participants must have large B-cell lymphoma of one of the following histologic subtypes by WHO criteria: * Diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS) * High grade B-cell lymphoma (HGBCL) with rearrangements of MYC and BCL2 and/or BCL6 * HGBCL NOS * EBV+ DLBCL * Primary mediastinal B-cell lymphoma * T-cell/histiocyte rich LBCL * Grade 3B follicular lymphoma * Large B-cell lymphoma transformed from underlying indolent NHL * PET measurable disease per Lugano criteria. * Relapsed or refractory disease treated with 1 prior systemic a…
Interventions
- DrugEpcoritamab
Bispecific IgG1 antibody
Locations (2)
- Massachusetts General HospitalBoston, Massachusetts
- Newton-Wellesley HospitalNewton, Massachusetts