Acute Effects of Ketone Supplementation and Alcohol on Brain Metabolism
University of Pennsylvania
Summary
The research study is being conducted to better understand the effects of ketones and alcohol on brain functioning and brain metabolism. Participants will be asked to undergo three identical MRI visits after three single-dose interventions: (1) drink a ketone supplement drink, (2) drink an alcoholic beverage, (3) no intervention. These interventions will be randomly assigned (meaning everyone receives all 3 interventions, but in different orders).
Description
Screening Visit: Participants will complete a screening visit at the CSA (Center for Studies of Addiction). At the visit participants will be asked to show legal photo identification and undergo a breath alcohol test to ensure a breath alcohol concentration (BrAC) of \<0.000%, to ensure that the participant is not intoxicated, which would make it difficult to provide informed consent. Participants will be given the informed consent form to read, which a study staff member will then review, as well as provide an explanation of the study protocol, risks, potential benefits, and alternative treat…
Eligibility
- Age range
- 21–65 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Able to provide written informed consent and commit to completing study procedures. 2. Reported on at least one day in the month before consent of consuming 2 or more standard alcoholic drinks on a single day. Exclusion Criteria: 1. Unwilling or unable to refrain from the use of psychoactive medications, medication that may affect study results, and or alcohol, within 24 hours of the Alcohol lab, and MRI procedures (self-report, medical history, UDS, and breathalyzer). 2. Current DSM-5 diagnosis of a major psychiatric disorder (other than marijuana and nicotine use di…
Interventions
- Dietary SupplementKenetik
Ketone supplement is randomly given once.
- OtherAlcohol beverage
Alcohol beverage is randomly given once. Participants will receive the alcohol beverage that dose-adjusts for body weight and sex differences in pharmacokinetics and calculated to obtain a final breath alcohol concentration of 0.050%
Location
- Center for Studies of AddictionPhiladelphia, Pennsylvania