Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome: A Non-randomized Prospective Trial (The BOOST Study)
Children's Mercy Hospital Kansas City
Summary
This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed hormone replacement therapy (HRT).
Eligibility
- Age range
- 12–20 years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * Diagnosis of Turner Syndrome and Primary Ovarian Insufficiency. * Prescribed adult dosing\* of transdermal or oral estradiol for estrogen replacement therapy. \*Adult dosing of will be defined per published clinical practice guidelines from the 2023 International Turner Syndrome Meeting (i.e. 50-200μg/day of transdermal estradiol, or (i.e. 50-200μg/day of transdermal estradiol or 2-4mg/day oral estradiol). * Have achieved menarche. Exclusion Criteria: * Disclosure of sexual activity and desire for contraception. * Having a levonorgestrel-releasing intrauterine devic…
Interventions
- DrugMicronized progesterone 200 MG
Oral micronized progesterone 200mg for the first 12 days of a 30 to 31-day cycle
- DrugMicronized Progesterone 100 MG
Oral micronized progesterone 100mg daily taken throughout the 30 to 31-day cycle.
Location
- Children's Mercy HospitalKansas City, Missouri