Memorial Sloan Kettering Cancer Center
The researchers are doing this study to find out whether the combination of abemaciclib and cabozantinib is a safe and effective treatment for people with metastatic clear cell renal cell carcinoma (ccRCC) and translocation-associated renal cell cancer (tRCC). The researchers will test different doses of the study drugs to find the highest doses that cause few or mild side effects in participants.
Inclusion Criteria: * Age ≥ 18 years at the time of informed consent * Patient must be able to provide informed consent, or a legal authorized representative (LAR) must be identified to provide consent in cases where the patient cannot * Signed and dated IRB-approved Informed Consent Form * Patient must have a histologically confirmed diagnosis of metastatic stage IV clear cell renal cell carcinoma or metastatic stage IV translocation-associated renal cell carcinoma. * Patient should have availability of archival tissue that enables definitive diagnosis of ccRCC or tRCC, per review at partici…
twice a day, orally
once daily, orally