A Multi-Center Observational Trial of Symptomatic, High-Risk Bone Metastases Treated With Percutaneous Ablation and Palliative Radiation Therapy
Society of Interventional Oncology
Summary
The objective of this study is to evaluate real-world outcomes (e.g., pain, patient reported outcomes, skeletal related events, healthcare utilization, etc.) in patients treated with both percutaneous ablation and palliative radiation therapy (RT).
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * 1\. Skeletal metastasis with localized pain not controlled medically \[recall within last 24 hours of worst pain ≥ 5 using the BPI\] * 2\. Pain must be from one painful metastatic lesion involving the bone (additional less painful metastatic sites may be present). Extra-osseous extension of disease is allowed (must have some contact with the bone and be causing bone/tumor interface pain) * 3\. Lesions that are at high-risk of skeletal related events defined as follows: * a. Minimum Spinal Instability Neoplastic Score (SINS) score ≥ 7 for lesions involving the spine * b.…
Interventions
- DevicePercutaneous Ablation
Percutaneous ablation is a minimally invasive alternative therapy for metastatic bone disease and can be used for destruction of nerves mediating pain signals, tumor destruction, decompression, or inhibition of tumor growth.
- RadiationRadiation Therapy
Radiation therapy (RT) is a widely accepted treatment for painful bone metastases and provides palliation of pain for patients.
Locations (6)
- University of California San Diego Moores Cancer CenterSan Diego, California
- Emory University HospitalAtlanta, Georgia
- Northside HospitalAtlanta, Georgia
- Mayo ClinicRochester, Minnesota
- Washington UniversitySt Louis, Missouri
- Medical College of WisconsinMilwaukee, Wisconsin