Safety of Short-term NSAID Use in the Postoperative Setting in Pediatric Patients With Chronic Kidney Disease
University of Colorado, Denver
Summary
The purpose of this study is to determine if non-steroidal anti-inflammatory (NSAID) use in the postoperative setting increases the risk of acute kidney injury (AKI) in pediatric patients with mild-to-moderate chronic kidney disease (CKD). The investigators hypothesize that there is no increased risk. This will be a limited pilot study within a Pediatric Urology population, intended to inform future work in a larger patient population.
Eligibility
- Age range
- 1+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients over 18 months of age * diagnosis of CKD stages 2-3a, confirmed by cystatin C laboratory testing within 6 months of surgery Exclusion Criteria: * diagnosis of CKD stage 1 or 4-5 * home medications of angiotensin converting enzyme inhibitors (ACEi, such as lisinopril or captopril) or angiotensin receptor blocker (ARB, such as losartan, valsartan) diuretics, or trimethoprim * IV contrast in last 30 days * PMH of renal transplant, diabetes, hypertension, nephrotic syndrome or heart failure, asthma, or hyperthyroidism * history of hyperkalemia * recent glucocortic…
Interventions
- DrugNSAIDs
IV formulation: ketorolac 0.5mg/kg/dose, 15mg maximum, no more than 8 doses total PO formulation: ibuprofen suspension 10mg/kg/dose, 400mg maximum Total duration (IV + PO) will not exceed 5 days.
- DrugPlacebo
IV or PO medication, compounded to have similar look, consistency and taste to the corresponding medications
Location
- Children's Hospital ColoradoAurora, Colorado