A Phase II, Multicenter, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of RO7790121 in Patients With Moderate to Severe Atopic Dermatitis
Hoffmann-La Roche
Summary
The purpose of this study is to assess the efficacy and safety of Afimkibart (also known as RO7790121) in participants with moderate to severe atopic dermatitis (AD).
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * AD diagnosis confirmed by a dermatologist according to the Hanifin/Rajka criteria at least 1 year prior to screening * Moderate to severe AD * At least once daily use of an additive-free, bland emollient for at least 7 days prior to the baseline visit and during the study Exclusion Criteria: * Evidence of other skin conditions that would interfere with the assessment of AD, including, but not limited to, for example cutaneous T-cell lymphoma, allergic contact dermatitis * IV, IM, IL, and oral corticosteroids (inhaled, ophthalmic drops, and nasal corticosteroids are all…
Interventions
- DrugAfimkibart
Afimkibart will be administered as SC injection.
- DrugPlacebo
Placebo will be administered as SC injection.
Locations (73)
- First OC DermatologyFountain Valley, California
- The Center for Dermatology Clinical ResearchFremont, California
- University of California Los AngelesLos Angeles, California
- Dermatology Research AssociateLos Angeles, California
- Suncoast Research Associates LLC - ERN - PPDSDoral, Florida
- Olympian Clinical ResearchTampa, Florida