Validation and Scaling of Screening Program for Undiagnosed Myasthenia Gravis-Social Media Campaign Paired With a Self-moderated Assessment
ZS Associates
Summary
This study expands and validates the pilot study NCT06381284. It is a fully remote, site-less, prospective, observational study enrolling adults in the United States (excluding U.S. territories) with undiagnosed neuromuscular symptoms. The primary objective is to determine the validity of a self-assessment tool in encouraging undiagnosed participants, recruited through a social media campaign, to seek medical evaluation for suspected myasthenia gravis (MG).
Description
The pilot study (NCT06381284) demonstrated the feasibility of using social media to recruit participants with undiagnosed MG-like neuromuscular symptoms. It also successfully led to the diagnosis of myasthenia gravis (MG) in previously undiagnosed individuals. In the pilot, two assessment tools were developed by the study team: the Impact of Daily Living (IDL) Survey and the MG Physical Tests. Both tools were designed using supporting literature, accepted guidelines, and a rigorous review via a panel of practicing neurologist key opinion leaders experienced in treating patients with MG. The p…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Reside within the 50 states of the United States at the time of enrollment * Age 19 or older if reside in Nebraska or Alabama, Age 21 or older if reside in Mississippi, Age 18 years or older if reside in any other state * Active email account * Fluency in English (spoken / written), as demonstrated by the ability to read and sign the Informed Consent Form Exclusion Criteria: * Live in an overseas territory of the United States * Inability or unwillingness to provide written informed consent * Diagnosed myasthenia gravis, including sero-negative MG\* * Diagnosed multipl…
Interventions
- BehavioralSocial media recruitment
Social media users exposed to a variety of paid social media advertisements as a recruitment tool for study enrollment
- BehavioralSelf-Assessment
Eligible participants are asked to complete self-administered physical tests to assess inducible fatigue of specific muscle groups
- BehavioralFollow-up
Patients triaged based on their assessed risk of MG are asked to complete recommended follow-up with a clinician to determine presence of myasthenia gravis
Location
- ZS AssociatesEvanston, Illinois