A Phase I Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of HS-20110 in Participants With Advanced Solid Tumors
Hansoh BioMedical R&D Company
Summary
This is an open-label, multicenter study to evaluate the safety and tolerability of HS-20110 in participants with advanced solid malignant tumors
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Males or females, aged ≥ 18 years. 2. Participants with pathologically (histologically or cytologically) confirmed advanced solid tumors. 3. Participants have at least 1 target lesion other than CNS lesions according to RECIST 1.1. Exclusion Criteria: 1. Participants have received or are receiving the following treatment: 1. Drug therapy targeting CDH17 (such as small molecule targeted drugs, monoclonal antibodies, bispecific antibodies, antibody-drug conjugates, or chimeric antigen receptor T cells). 2. Anti-tumor drugs within 14 days prior to the first dose o…
Interventions
- DrugHS-20110 (Phase Ia:Dose escalation )
HS-20110 for IV infusion of various dose strengths administered in 21 day dosing cycles
- DrugHS-20110 (Phase Ib:Dose expansion )
The recommended dose from the dose-escalation stage and other potential doses will be further explored
Locations (8)
- BRCR Medical Center INCTamarac, Florida
- Fort Wayne Medical Oncology and HematologyFort Wayne, Indiana
- Carolina BioOncology InstituteHuntersville, North Carolina
- The University of Texas MD Anderson Cancer CenterHouston, Texas
- NEXT DallasIrving, Texas
- NEXT OncologySan Antonio, Texas