Processing Intergenerational Trauma With Psilocybin-Assisted Therapy
Rachel Yehuda
Summary
This is an open-label psilocybin-assisted therapy study that will examine the safety and tolerability of psilocybin-assisted therapy in the offspring of genocide survivors with mood and anxiety disorders. The study will also investigate the efficacy of psilocybin-assisted therapy in reducing symptoms such as depression, anxiety and stress, as well as changes to the psychological effects of parental exposure to genocide, and changes to psychological resilience.
Description
This study is investigating whether Psilocybin-assisted therapy improves depression, anxiety and stress symptoms in the offspring (biological children) of genocide survivors. Intergenerational trauma is the concept that the effects of experiencing extreme stress can be perpetuated to future generations. A genocide here is defined by the extinction or threat of extinction of a racial, religious or ethnic group, by an oppressive regime. A genocide survivor here is defined by an individual who survived or escaped a genocide in their country of origin. Currently, there are no evidence-based treatm…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age at least 18 years old at time of signing the informed consent. * Biological child of at least one parent who directly survived/escaped a genocide. * Evidence of clinically significant intergenerational trauma-related symptoms, as determined by the modified Parental PTSD Questionnaire (mPPQ). * Meet diagnostic criteria for a depressive, anxiety, trauma-, or stressor-related disorder on the Structured Clinical Interview for DSM-5 (SCID-5). * BMI of ≥ 17. * Capable of providing written informed consent and complying with study procedures. * If of reproductive potential,…
Interventions
- DrugPsilocybin
Psilocybin 25mg, capsules taken orally under the supervision of two trained study therapists
- BehavioralIntegration sessions
weekly integration sessions (therapy) for 6 weeks
Location
- The Parsons Research Center for Psychedelic HealingNew York, New York