Determination of Microbiome Diversity and Inflammation Throughout the GI Tract During Endurance Exercise
Stanford University
Summary
The small intestine and feces of subjects undergoing endurance exercise will be sampled to examine their microbiome composition
Description
The close relationship between humans and the commensal microbes of their gut microbiota represents vast potential for health maintenance, but most efforts have been focused on disease. Gastrointestinal (GI) problems are very common especially in endurance athletes, and are known to impair performance or subsequent recovery. Moreover, GI symptoms among athletes vary enormously, and some athletes are more prone than others; the links between this variation and the differences in microbiome composition across individuals have not been elucidated. The investigators propose to use a novel, non-inv…
Eligibility
- Age range
- 18–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Subjects must meet all of the following criteria to be included in the study: * Males or females 18 years of age or older and 70 years of age or younger at the time of the first Screening Visit. * ASA Classifications 1 and 2. * For women of childbearing potential, negative urine pregnancy test within 7 days of Screening Visit. Willingness to use highly effective contraception during the entire study period (e.g.: implants, injectables, oral contraceptives, intra-uterine device or declared abstinence). * Subject is fluent in English and understands the study protocol and i…
Interventions
- OtherTreadmill Exercise
Participants perform moderate to strenuous exercise for up to 20 minutes on a treadmill after swallowing a microbiome sampling capsule.
- DeviceCooling Gloves
Cooling gloves to prevent rise in core body temperature during exercise
- DeviceMicrobiome Capsule
Capsule used for collecting intestinal tract contents
Location
- Stanford UniversityStanford, California