Absorption and Tolerability of Injectable Administration of Niagen®+, Nicotinamide Riboside Chloride, a Specialized Form of Vitamin B3, as Compared to NAD+: a Double Blinded, Randomized, Controlled Clinical Trial
Nutraceuticals Research Institute
Summary
This study evaluates the subjective effects of injection administration of NR on healthy adult populations.
Description
The purpose of this work is to explore the tolerability of Niagen®, nicotinamide riboside chloride, a specialized form of vitamin B3, via intramuscular (IM), subcutaneous (SQ), and intravenous-push (IVP) administration, in comparison to NAD+, an active comparator, administered through the same routes.
Eligibility
- Age range
- 40–65 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness and demonstrated ability to comply with all study procedures, as well as availability for the duration of the study * Lives within 100 miles of the NRI study site * Any gender, aged 40-65, inclusive * Good general health as evidenced by medical history * BMI 25-34.9 kg/m2 * Sedentary behavior (defined as \<20 minutes per day or 100 minutes per week of moderate to vigorous exercise) * Demonstrated fatigue (Fatigue Assessment Scale) defined as a below-average score * For females of reproductive potent…
Interventions
- Dietary SupplementNiagen®
nicotinamide riboside
- OtherNAD+
Nicotinamide adenine dinucleotide
- OtherPlacebo
bacteriostatic water
Location
- Nutraceuticals Research InstituteHuntsville, Alabama