Physical Rehabilitation of Long COVID by Heat Therapy
University of Nebraska
Summary
Post-acute sequelae of SARS-CoV-2 infection (PASC) is becoming a major risk factor for chronic diseases, with older adults and those with underlying health conditions at risk of developing persistent mobility limitations and disabilities. Although exercise intervention is a common strategy to restore functional capacity, it may not be feasible or enticing to many people with PASC. This clinical trial seeks to establish the tolerability and efficacy of at home lower-body heat therapy for improving functional capacity along with metabolic and vascular health in late-middle aged and older adults with PASC, also known as "long COVID".
Description
Post-acute sequelae of SARS-CoV-2 infection (PASC) affects 5 out of 10 patients hospitalized for the coronavirus disease 2019 (COVID-19) and \~11% of all adults infected by SARS-CoV-2, which makes this condition a growing public health concern. It is associated with important disabilities, cognitive dysfunction, and increased risks for cardiovascular and metabolic diseases. Although exercise-based intervention is a promising rehabilitation strategy, participation rates are commonly low in clinical population. In addition, post-exertional malaise, a common symptom with PASC, is a major safety c…
Eligibility
- Age range
- 50–90 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Between the ages of 50 and 90 years * Free from orthopedic limitations that would prohibit performing leg exercise * BMI \< 40 kg/m2 and weigh \< 400lbs * Previously contracted Covid-19 and have persistent symptoms such as a fatigue or decline in physical function, for at least 2 months following SARS-CoV-2 infection Exclusion Criteria: * Unable to give written informed consent * Women who are pregnant, breastfeeding, or likely to become pregnant within the next 6 months * Women who are taking hormone therapy * Claustrophobia * Orthopedic limitations that would prohibi…
Interventions
- BehavioralHeat therapy
At home lower body heat therapy
- BehavioralSham Control
Sham Thermoneutral
- BehavioralWalking
Walking intervention
Location
- University of Nebraska OmahaOmaha, Nebraska